… percutaneous absorption of hazardous substances in humans. In our study, the percutaneous
penetration of 2-butoxyethanol (BE) and toluene was compared in different rat models. …

… Toxic substances are present in workplaces and the … In vitro/in vivo comparison using animal
models can also be … There are considerable differences between the two standards with …

… skin penetration research is to assess the risk to human beings after dermal exposure to
hazardous chemicals… both physiological and structural differences between species, which may …

… animal models are still valuable for dermal risk assessment. … predictions of dermal absorption
of toxic chemicals’’ (EDETOX)… The pig as an experimental animal model of percutaneous …

… at 24 h, while rat models overestimated the human skin … indicated that evaluation of %
percutaneous absorption over … This in vivo/in vitro difference was not observed in the rat models, …

… was fairly close agreement among the percutaneous penetration values determined for DEM
… Hg at 20Q may limit skin penetration to the extent that differences between the models fade. …

… skin to PA in vivo was assessed by comparing our results with … in vivo and in vitro human
and animal skin penetration data and (b) … difference, the absorption of PA in the pig skin model …

… differences in penetration rates is necessary in order to extrapolate animal data from PBPK
models … The PCs were considered as predictors of percutaneous penetration for the purpose …

… penetration between rat and man for a total of 14 chemicals in … demonstrating large differences
in the rate of skin penetration. … Rat skin is the membrane type of choice in percutaneous in …

… assumed values for percutaneous penetration of various flame … The difference between the
calculated PA values for soil … when extrapolating results from animal models to humans. This …